| ESM1 |
| LOCUS ID | 11082 | ||||||||||
| GENE_SYMBOL | ESM1 | ||||||||||
| GENE NAME | endothelial cell spe | ||||||||||
| SYNONYMNS | endocan | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 5107 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. Apelin,endoglin and endocan might be associated with endothelial dysfunction,angiogenesis and inflammation mechanism which play some role in DPN pathogenesis. | 27010147 |