| EXOSC7 |
| LOCUS ID | 23016 | ||||||||||
| GENE_SYMBOL | EXOSC7 | ||||||||||
| GENE NAME | exosome component 7 | ||||||||||
| SYNONYMNS | p8, EAP1, RRP42, Rrp42p, hRrp42p | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 8994 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| EXOSC7 (Exosome Component 7) is a Protein Coding gene. Diseases associated with EXOSC7 include X-Linked Nephrolithiasis Type I. Among its related pathways are Metabolism of proteins and PERK regulates gene expression. Gene Ontology (GO) annotations related to this gene include RNA binding and exoribonuclease activity. An important paralog of this gene is EXOSC8. |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. p8 is also induced in diabetic kidney. Small interfering R (siR)-mediated R interference indicates that p8 is required for endothelin-induced hypertrophy. Thus, p8 is a novel marker for diabetic renal hypertrophy. | 12374743 |