| F11 |
| LOCUS ID | 2160 | ||||||||||
| GENE_SYMBOL | F11 | ||||||||||
| GENE NAME | coagulation factor X | ||||||||||
| SYNONYMNS | FXI | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 86654 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains h |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. However, in the microalbuminuric (17.9 +/- 3. 9 ng/ml; n = 16) and albuminuric (24.1 +/- 5.4 ng/ml; n = 10) groups, FXIa-alpha 1AT levels were significantly increased compared with those in the control and normoalbuminuric group. | 8425659 |