| F2R |
| LOCUS ID | 2149 | ||||||||||
| GENE_SYMBOL | F2R | ||||||||||
| GENE NAME | coagulation factor I | ||||||||||
| SYNONYMNS | TR, HTR, CF2R, PAR1, PAR-1 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 1510 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The up-regulation of PAR-1 in glomeruli in diabetic mice may play a role in the progression of glomerulosclerosis and abnormal Urinary albumin excretion in diabetic nephropathy. | 19401193 |