| F2RL1 |
| LOCUS ID | 2150 | ||||||||||
| GENE_SYMBOL | F2RL1 | ||||||||||
| GENE NAME | F2R like trypsin rec | ||||||||||
| SYNONYMNS | PAR2 GPR11 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 21087 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in th |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In conclusion, this study demonstrated that PAR2 activation-induced M1 polarization and inflammation through the FOXO1-dependent pathway. | 30552714 |