| F8 |
| LOCUS ID | 2157 | ||||||||||
| GENE_SYMBOL | F8 | ||||||||||
| GENE NAME | coagulation factor V | ||||||||||
| SYNONYMNS | AHF,F8B,F8C,HEMA,FVIII,DXS1253E | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 49153 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. Diabetics with neuropathy showed significantly elevated FVIII and vWF in comparison with diabetics without neuropathy and controls. | 8403679 |