Go to Advanced Search
FABP5 |
LOCUS ID | 2171 | |||||||||||||||||||
GENE_SYMBOL | FABP5 | |||||||||||||||||||
GENE NAME | fatty acid binding p | |||||||||||||||||||
SYNONYMNS | EFABP, KFABP, E-FABP, P | |||||||||||||||||||
CHROMOSOME | 8 | |||||||||||||||||||
HOMOLOGENE ID | 108238 |
microRNAs | NA | NA |
GENE SUMMARY |
---|
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[prov |
OBSERVATIONS |
---|
Complication | Evidence | PMID |
Cardiovascular | 1. These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus. | 20920650 |
Atherosclerosis | 1. This study provides evidence for an additive relation of FABP4 and FABP5 with the metabolic syndrome, inflammatory cardiovascular disease risk factors, and corory atherosclerosis in type 2 diabetes mellitus | 20920650 |
Dyslipidemia | 1. The FABP5 plasma levels were positively correlated with adiposity, glucose metabolism, and lipolysis parameters and were associated with AD, as assessed by NMR. | 27055964 |
Insulin resistance and Inflammation | 1. These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus. | 20920650 |