| FAS |
| LOCUS ID | 355 | ||||||||||
| GENE_SYMBOL | FAS | ||||||||||
| GENE NAME | Fas cell surface dea | ||||||||||
| SYNONYMNS | APT1 CD95 FAS1 APO-1 FASTM ALPS1A TNFRSF6 | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 27 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Though high-fat fed FASKO mice had no beta-cell phenotype, they were hypophagic and hypermetabolic, and they had increased insulin sensitivity at the liver but not the periphery as demonstrated by hyperinsulinemic-euglycemic clamps, and biochemically by increased phosphorylated Akt, glycogen synthase kinase-3beta, and FOXO1 compared with wild-type mice. | 19029118 |