| FBXW7 |
| LOCUS ID | 55294 | ||||||||||
| GENE_SYMBOL | FBXW7 | ||||||||||
| GENE NAME | F-box and WD repeat | ||||||||||
| SYNONYMNS | AGO CDC4 FBW6 FBW7 hAgo FBX30 FBXW6 SEL10 hCdc4 FBXO30 SEL-10 | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 117451 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modul |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. FBXW7 markedly ameliorated hepatic inflammation and insulin resistance in the HFD-fed mice.?Our results demonstrate a protective role of FBXW7 in NAFLD by abating HMGB1-mediated innate immune signaling to suppress inflammation and consequent insulin resistance. | 31215394 |