| FFAR1 |
| LOCUS ID | 2864 | ||||||||||
| GENE_SYMBOL | FFAR1 | ||||||||||
| GENE NAME | free fatty acid rece | ||||||||||
| SYNONYMNS | FFA1R, GPR40, GPCR40 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 3876 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. Furthermore, in response to conjugated linoleic acids or trans isomers of arachidonic acid, GPR40 was recently demonstrated in rodents to mediate lipotoxicity to beta-cells, neurons, or microvessels, which in diabetes, retinopathy, stroke, etc. | 25615413 |