GENE NAMEfibroblast growth fa
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]


Complication Evidence PMID
Nephropathy1. Elevated serum FGF21 levels may be a useful biomarker for predicting kidney disease progression especially in early stages of diabetic nephropathy. 2. Our suggest that FGF21 improves insulin resistance and protects against renal injury through both improvement of systemic metabolic alterations and antifibrotic effects in type 2 diabetic nephropathy.25625802
Cardiovascular1. Higher baseline plasma FGF21 levels were associated with higher risk of cardiovascular events in patients with type 2 diabetes.25425220
Retinopathy1. Higher baseline FGF21 levels are seen in patients with type 2 diabetes and established microvascular disease, and predict the future development of new microvascular disease.26055067
Atherosclerosis1. In humans, circulating FGF21 levels are elevated in corory heart disease and atherosclerosis, and are associated with a higher risk of cardiovascular events in patients with type 2 diabetes.26379627
Dyslipidemia1. In logistic regression analysis, circulating FGF21 was found to be an independent predictor for subclinical atherosclerosis (P?=?0.023) in addition to dyslipidemia, hypertension and adiponectin.26379627
Insulin resistance and inflammation1. these results indicate that circulating levels of FGF21 are increased in patients presenting with sepsis and SIRS, and suggest a role for FGF21 in inflammation. 30641825