| FMOD |
| LOCUS ID | 2331 | ||||||||||
| GENE_SYMBOL | FMOD | ||||||||||
| GENE NAME | fibromodulin | ||||||||||
| SYNONYMNS | FM, SLRR2E | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 1530 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. These observations support previous experimental findings in mice for a role of fibromodulin in atherosclerosis and provide clinical evidence of the involvement of fibromodulin in the inflammatory processes that characterize atherosclerotic plaque vulnerability. | 26125412 |