| FN3K |
| LOCUS ID | 64122 | ||||||||||
| GENE_SYMBOL | FN3K | ||||||||||
| GENE NAME | fructosamine 3 kinas | ||||||||||
| SYNONYMNS | NONE | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 23336 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functiol. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. We found combined effect of TKT SNP rs11130362 and FN3K SNP rs1056534 on DN progression (p<0.01). | 23492569 |