| FNDC5 |
| LOCUS ID | 252995 | |||||||||||||
| GENE_SYMBOL | FNDC5 | |||||||||||||
| GENE NAME | fibronectin type III | |||||||||||||
| SYNONYMNS | FRCP2, irisin | |||||||||||||
| CHROMOSOME | 1 | |||||||||||||
| HOMOLOGENE ID | 17812 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. There is an association of FNDC5 rs16835198 G>T polymorphism with T2DM, diabetic nephropathy and irisin levels; FNDC5 rs16835198 TT genotype associates with decreased risk of T2DM in Egyptians with no effect on renal complications | 28479383 |
| Insulin resistance and inflammation | 1. FNDC5 overexpression attenuated insulin resistance, AMPK inhibition, M1 macrophage polarization and inflammatory cytokine production in adipose tissue of obese WT and FNDC5-/- mice. | 29374559 |