| FOLH1 |
| LOCUS ID | 2346 | ||||||||||
| GENE_SYMBOL | FOLH1 | ||||||||||
| GENE NAME | folate hydrolase (pr | ||||||||||
| SYNONYMNS | PSM,FGCP,FOLH,GCP2,PSMA,mGCP,GCPII,ALAD1,ALAdase | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 136782 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate l |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. GCPII inhibition has beneficial effects on hyperalgesia, nerve function, and structural degenerative changes in DPN, which are likely mediated by inhibition of ischemia-induced glutamate release. | 11809162 |