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FOS |
LOCUS ID | 2353 | ||||||||||||||||
GENE_SYMBOL | FOS | ||||||||||||||||
GENE NAME | FBJ murine osteosarc | ||||||||||||||||
SYNONYMNS | p55, AP-1, C-FOS | ||||||||||||||||
CHROMOSOME | 14 | ||||||||||||||||
HOMOLOGENE ID | 3844 |
microRNAs | NA | NA |
GENE SUMMARY |
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The Fos gene family consists of 4 membersFOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. Increased intracellular ROS generation in PBMCs of diabetic patients is involved in the pathogenesis of diabetic nephropathy via activation NF-kappaB and AP-1 and an increased expression of TGF-beta1. | 18485515 |
Neuropathy | 1. Computational analysis reveal that out of 99 identified key hub gene candidates from 348 DEGs, only four genes (CCL2, ELMO1, VEGFA and TCF7L2) along with FOS playing key role in causing T2D and its associated disorders, like nephropathy, neuropathy, rheumatoid arthritis and cancer via p53 or Wnt signaling pathways. | 30708140 |
Insulin resistance and inflammation | 1. The majority of differentially expressed genes were down-regulated after profound fat loss, including transcription factors involved in stress response, inflammation, and immune cell function (e.g., FOS, JUN, ETS, C/EBPB, C/EBPD). | 20543949 |