| FOXA2 |
| LOCUS ID | 3170 | ||||||||||
| GENE_SYMBOL | FOXA2 | ||||||||||
| GENE NAME | forkhead box A2 | ||||||||||
| SYNONYMNS | HNF3B, TCF3B | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 7762 |
| microRNAs | miR-124/29 | 22156553 |
| GENE SUMMARY |
|---|
| This gene encodes a member of the forkhead class of D-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. haploinsufficient Foxa2(+/-) mice exhibited decreased hepatic apoM expression and plasma pre-beta-HDL and HDL levels. | 18381283 |