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FOXO1 |
LOCUS ID | 2308 | ||||||||||||||||
GENE_SYMBOL | FOXO1 | ||||||||||||||||
GENE NAME | forkhead box O1 | ||||||||||||||||
SYNONYMNS | FKH1, FKHR, FOXO1A | ||||||||||||||||
CHROMOSOME | 13 | ||||||||||||||||
HOMOLOGENE ID | 1527 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Atherosclerosis | 1. FOXO1 deacetylation can promote vascular endothelial changes conducive to atherosclerotic plaque formation. Experiments in isolated endothelial cells from Foxo1(KR/KR) mice indicate that deacetylation favors FoxO1 nuclear accumulation and exerts target gene-specific effects, ing in higher Icam1 and TnfA expression and increased monocyte adhesion. The data indicate that FoxO1 deacetylation can promote vascular endothelial changes conducive to atherosclerotic plaque formation. | 22389493 |
Nephropathy | 1. FOXO1 play an important role in the pathogenesis of diabetic nephropathy (DN). | 28860538 |
Insulin resistance and inflammation | 1. Furthermore, augmented hepatic FOXO1 expression and decreased phosphorylation were found to be associated with elevated pro-inflammatory cytokine production in high fat diet-induced obese and db/db mice. | 22223069 |