GENE NAMEglucose-6-phosphate
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce DPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cau


Complication Evidence PMID
Nephropathy1. This study investigated whether SPR ameliorates nephropathy by increasing G6PD activity and reducing oxidative stress in spontaneously hypertensive diabetic rats (SHRs).21987533
Cardiovascular1. Thus G6PD may be a useful therapeutic target for treating the cardiovascular disease associated with type 2 diabetes, if second-generation drugs specifically reducing the activity of G6PD to near normal levels are developed19429815
Neuropathy1. The frequency of G6PD deficiency in patients with NAION was significantly lower than expected. suggest that G6PD-deficient patients in the Sardinian population have a significantly decreased risk of having NAION.18385045
Retinopathy1. Poor glycemia levels along with increased generation of ALEs might be the major contributing biochemical derangements associated with decreased G6PD activity followed by low NADPH levels in subjects with MNPDR, thus increasing the vulnerability of erythrocytes to oxidative stress in the early course of retinopathy.27916496
Insulin resistance and inflammation1. Adipogenic G6PD overexpression promotes the expression of pro-oxidative enzymes, including inducible nitric oxide synthase and NADPH oxidase, and the activation of nuclear factor-kappaB (NF-kappaB) signaling, which eventually leads to the dysregulation of adipocytokines and inflammatory signals. 17065329