| GALR2 |
| LOCUS ID | 8811 | ||||||||||
| GENE_SYMBOL | GALR2 | ||||||||||
| GENE NAME | galanin receptor 2 | ||||||||||
| SYNONYMNS | GAL2-R GALNR2 GALR-2 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 2863 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein- |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In conclusion, activation of central GALR2 promotes glucose metabolism and ameliorates insulin resistance mainly through the PGC-1?/GLUT4 pathways. | 30170096 |