| GAP43 |
| LOCUS ID | 2596 | ||||||||||
| GENE_SYMBOL | GAP43 | ||||||||||
| GENE NAME | growth associated pr | ||||||||||
| SYNONYMNS | B-50, PP46 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 1545 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axol regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Altertively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. Our present findings are in accordance with these observations and extent previous findings by demonstrating a markedly decreased expression of Nf68 and GAP43 in sciatic nerve of hyperglycemic ob/ob compared with normoglycemic ob/+ mice. | 22412941 |