GAPDH
LOCUS ID2597
GENE_SYMBOLGAPDH
GENE NAMEglyceraldehyde-3-pho
SYNONYMNSG3PD, GAPD, HEL-S-162eP
CHROMOSOME12
HOMOLOGENE ID107053
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (D). The encoded protein has a

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. High glucose decreased GAPDH activity, expression, and nuclear translocation.In hyperglycemia, GAPDH in retinal microvascular cells is inhibited by its covalent modifications, and this activates multiple pathways implicated in the pathogenesis of diabetic retinopathy.19875652
Neuropathy1. PARP activation, on one hand, depletes its substrate, NAD+, slowing the rate of glycolysis, electron transport and ATP formation. On the other hand, PARP activation in inhibition of GAPDH by poly-ADP-ribosylation. These processes in acute endothelial dysfunction in diabetic blood vessels, which importantly contributes to the development of various diabetic complications.15962096