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GAPDH |
LOCUS ID | 2597 | |||||||||||||
GENE_SYMBOL | GAPDH | |||||||||||||
GENE NAME | glyceraldehyde-3-pho | |||||||||||||
SYNONYMNS | G3PD, GAPD, HEL-S-162eP | |||||||||||||
CHROMOSOME | 12 | |||||||||||||
HOMOLOGENE ID | 107053 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (D). The encoded protein has a |
OBSERVATIONS |
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Complication | Evidence | PMID |
Retinopathy | 1. High glucose decreased GAPDH activity, expression, and nuclear translocation.In hyperglycemia, GAPDH in retinal microvascular cells is inhibited by its covalent modifications, and this activates multiple pathways implicated in the pathogenesis of diabetic retinopathy. | 19875652 |
Neuropathy | 1. PARP activation, on one hand, depletes its substrate, NAD+, slowing the rate of glycolysis, electron transport and ATP formation. On the other hand, PARP activation in inhibition of GAPDH by poly-ADP-ribosylation. These processes in acute endothelial dysfunction in diabetic blood vessels, which importantly contributes to the development of various diabetic complications. | 15962096 |