| GAS6 |
| LOCUS ID | 2621 | ||||||||||
| GENE_SYMBOL | GAS6 | ||||||||||
| GENE NAME | growth arrest specif | ||||||||||
| SYNONYMNS | AXSF, AXLLG | ||||||||||
| CHROMOSOME | 13 | ||||||||||
| HOMOLOGENE ID | 638 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic nephropathy is prevented by warfarin-induced inhibition of GAS6 protein. | 25869052 |