| GATA2 |
| LOCUS ID | 2624 | ||||||||||
| GENE_SYMBOL | GATA2 | ||||||||||
| GENE NAME | GATA binding protein | ||||||||||
| SYNONYMNS | DCML IMD21 NFE1B MONOMAC | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 32030 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We show that insulin induces GATA2 phosphorylation on serine 401 in a PI-3K/Akt-dependent manner. Insulin-dependent phosphorylation of serine 401 impairs GATA2 translocation to the nucleus and its DNA binding activity. | 15837948 |