| GATA3 |
| LOCUS ID | 2625 | ||||||||||
| GENE_SYMBOL | GATA3 | ||||||||||
| GENE NAME | GATA binding protein | ||||||||||
| SYNONYMNS | HDR HDRS | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 1550 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Gene expression of NLRP3, CASPASE-1, CD3? (pan T cells), TBX21 (T(h)1 cells) and RORC (T(h)17 cells) was positively, whereas GATA3 (T(h)2 cells) was inversely correlated with AT inflammation. | 22325453 |