| GDF15 |
| LOCUS ID | 9518 | ||||||||||||||||
| GENE_SYMBOL | GDF15 | ||||||||||||||||
| GENE NAME | growth differentiati | ||||||||||||||||
| SYNONYMNS | PDF, MIC1, PLAB, MIC-1, G-1, PTGFB, GDF-15 | ||||||||||||||||
| CHROMOSOME | 19 | ||||||||||||||||
| HOMOLOGENE ID | 3576 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Sep 2015] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. GDF15 protects the renal interstitium and tubular compartment in experimental type 1 and 2 diabetes without affecting glomerular damage. | 23986522 |
| Cardiovascular | 1. the level of GDF15 may be a useful predictive biomarker of cardiovascular risk in newly diagnosed T2D patients. | 27510384 |
| Insulin resistance and inflammation | 1. Here we report that female hNAG-1 mice (mice expressing hNAG-1/hGDF15 have been shown to be resistant to HFD-induced obesity and inflammation) had significantly increased both mean and median life spans in two transgenic lines, with a larger difference in life spans in mice on a HFD than on low fat diet. | 25239873 |