| GFRA2 |
| LOCUS ID | 2675 | ||||||||||
| GENE_SYMBOL | GFRA2 | ||||||||||
| GENE NAME | GDNF family receptor | ||||||||||
| SYNONYMNS | NTNRA, RETL2, TRNR2, GDNFRB, NRTNR-ALPHA | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 131781 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN comp |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. We identified four genes differentially expressed between the two study arms post-treatment, but not pre-treatment: GFRA2 (GDNF family receptor alpha-2), C1QBP (complement C1q binding protein), RAB35 (member of RAS oncogene family) and SYNJ1 (synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1). | 30221321 |