Go to Advanced Search
GGT2 |
LOCUS ID | 728441 | ||||||||||
GENE_SYMBOL | GGT2 | ||||||||||
GENE NAME | gamma-glutamyltransf | ||||||||||
SYNONYMNS | GGT, GGT, 2 | ||||||||||
CHROMOSOME | 22 | ||||||||||
HOMOLOGENE ID | 68450 |
microRNAs | NA | NA |
GENE SUMMARY |
---|
GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008] |
OBSERVATIONS |
---|
Complication | Evidence | PMID |
Nephropathy | 1. Urinary GGT and ALP have potential value in the diagnosis of nephropathy in type 2 diabetic patients, but GGT has a slightly higher ability to discrimite nephropathy than ALP. | 21527256 |