| GHRH |
| LOCUS ID | 2691 | ||||||||||
| GENE_SYMBOL | GHRH | ||||||||||
| GENE NAME | growth hormone relea | ||||||||||
| SYNONYMNS | GRF INN GHRF | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 7731 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded prot |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress resistance, and insulin signaling. | 24175087 |