| GHSR |
| LOCUS ID | 2693 | ||||||||||
| GENE_SYMBOL | GHSR | ||||||||||
| GENE NAME | growth hormone secre | ||||||||||
| SYNONYMNS | GHDP | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 57161 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutiory conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Single-locus analyses showed significant main effects of ENPP1 (P = 0.0032; adjusted OR = 1.85; 95% CI = 1.17-2. 92) on the risk of DN in T2D. Furthermore, a potential gene-gene interaction involving ENPP1 and GHSR was suggested in the best two-locus GMDR model (P = 0.021). | 18575614 |