| GNPDA2 |
| LOCUS ID | 132789 | ||||||||||
| GENE_SYMBOL | GNPDA2 | ||||||||||
| GENE NAME | glucosamine-6-phosph | ||||||||||
| SYNONYMNS | GNP2,SB52 | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 12381 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. Interestingly, the novel SNP rs1996023 is located at protein coding gene GNPDA2 (ccFDR?=?1.28E-02), which has been reported to influence the risk of T2D and CO through central nervous system. | 30816286 |