| GPC5 |
| LOCUS ID | 2262 | ||||||||||
| GENE_SYMBOL | GPC5 | ||||||||||
| GENE NAME | glypican 5 | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 13 | ||||||||||
| HOMOLOGENE ID | 3285 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Among cases of diabetes mellitus nephropathy (DN), the major complication of type 2 diabetes mellitus, the nephrotic phenotype is often intractable to clinical intervention and demonstrates the rapid decline of renal function to end-stage renal disease. We recently identified the gene for glypican-5 (GPC5), a cell-surface heparan sulfate proteoglycan, as conferring susceptibility for acquired nephrotic syndrome and additionally identified an association through a genome-wide association study between a variant in GPC5 and DN of type 2 diabetes mellitus. | 25987249 |