| GPER1 |
| LOCUS ID | 2852 | ||||||||||
| GENE_SYMBOL | GPER1 | ||||||||||
| GENE NAME | G protein-coupled es | ||||||||||
| SYNONYMNS | mER CEPR GPER DRY12 FEG-1 GPR30 LERGU LyGPR CMKRL2 LERGU2 GPCR-Br | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 15855 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongeno |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. GPER action manifests pleiotropic effects in metabolically active tissues such as the pancreas, adipose, liver, and skeletal muscle ; GPER deficiency leads to increased adiposity, insulin resistance, and metabolic dysfunction in mice. | 29224106 |