| GPR119 |
| LOCUS ID | 139760 | ||||||||||
| GENE_SYMBOL | GPR119 | ||||||||||
| GENE NAME | G protein-coupled re | ||||||||||
| SYNONYMNS | GPCR2 | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 18670 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Deletion of GPR43 and GPR84 exacerbates inflammation, and deletion of the long-chain fatty acid receptors GPR119 and GPR120 reduces or is predicted to reduce glucose tolerance. | 21587066 |