| GPR21 |
| LOCUS ID | 2844 | ||||||||||
| GENE_SYMBOL | GPR21 | ||||||||||
| GENE NAME | G protein-coupled re | ||||||||||
| SYNONYMNS | |||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 74546 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the G-protein-coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. The encoded protein activates a Gq signal transduction pathway which mobilizes calcium. [provided by RefSeq, Nov 2012] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Furthermore, mice lacking macrophage expression of Gpr21 were protected from HFD-induced inflammation and displayed improved insulin sensitivity. | 22653059 |