| GPRC5B |
| LOCUS ID | 51704 | ||||||||||
| GENE_SYMBOL | GPRC5B | ||||||||||
| GENE NAME | G protein-coupled re | ||||||||||
| SYNONYMNS | RAIG2 RAIG-2 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 9435 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. We demonstrated that a GPRC5B mutant lacking the direct binding site for Fyn failed to activate a positive feedback loop of nuclear factor ?B-inhibitor of ?B kinase ? signaling. | 23169819 |