| GPS2 |
| LOCUS ID | 2874 | ||||||||||
| GENE_SYMBOL | GPS2 | ||||||||||
| GENE NAME | G protein pathway su | ||||||||||
| SYNONYMNS | AMF-1 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 49599 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. A co-repressor complex containing G protein pathway suppressor 2 (GPS2) crucially controls the macrophage epigenome during activation by metabolic stress. | 27270589 |