| GPX1 |
| LOCUS ID | 2876 | |||||||||||||
| GENE_SYMBOL | GPX1 | |||||||||||||
| GENE NAME | glutathione peroxida | |||||||||||||
| SYNONYMNS | GPXD, GSHPX1 | |||||||||||||
| CHROMOSOME | 3 | |||||||||||||
| HOMOLOGENE ID | 20155 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalani |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. The presence of Pro197Leu substitution of the GPx-1 gene may play a crucial role in determining genetic susceptibility to corory-arteriosclerosis in T2D. 2. Ebselen, a glutathione peroxidase 1 (GPX1) mimic, has been shown to improve beta-cell function in diabetes and prevent atherosclerosis. | 17825092 |
| Retinopathy | 1. We identified differential DNA methylation of 349 CpG sites representing 233 unique genes including TNF, CHI3L1 (also known as YKL-40), CHN2, GIPR, GLRA1, GPX1, AHRR, and BCOR in cases with PDR compared with controls. | 26248552 |