| GRB10 |
| LOCUS ID | 2887 | ||||||||||
| GENE_SYMBOL | GRB10 | ||||||||||
| GENE NAME | growth factor recept | ||||||||||
| SYNONYMNS | RSS,IRBP,MEG1,GRB-IR,Grb-10 | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 3882 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Glucose intolerance was attributable to carrageenan-induced inflammation and to increased expression of GRB10.? | 31179345 |