| GRK2 |
| LOCUS ID | 156 | |||||||||||||
| GENE_SYMBOL | GRK2 | |||||||||||||
| GENE NAME | G protein-coupled re | |||||||||||||
| SYNONYMNS | BARK1 ADRBK1 BETA-ARK1 | |||||||||||||
| CHROMOSOME | 11 | |||||||||||||
| HOMOLOGENE ID | 0 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart fa |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. It also unveils GRK2 as a link between cardiovascular pathologies and co-morbidities such as obesity or type 2 diabetes | 28389415 |
| Insulin resistance and inflammation | 1. GRK2 appears a promising target, given its established role in insulin resistance and in systolic heart failure. Using a custom peptide inhibitor of GRK2, we assessed in vitro in L6 myoblasts the effects of GRK2 inhibition on glucose extraction and insulin signaling. | 30934608 |