| GSTT1 |
| LOCUS ID | 2952 | |||||||||||||||||||
| GENE_SYMBOL | GSTT1 | |||||||||||||||||||
| GENE NAME | glutathione S-transf | |||||||||||||||||||
| SYNONYMNS | NA | |||||||||||||||||||
| CHROMOSOME | 22 | |||||||||||||||||||
| HOMOLOGENE ID | 0 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotyp |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Association of diabetic nephropathy (DN) with the deletion of GSTT1 and GSTM1 genes is well reported. | 20521623 |
| Cardiovascular | 1. Genetic absence of the GSTT1 enzyme is an independent and powerful predictor of premature vascular morbidity and death in individuals with type 2 diabetes | 15927971 |
| Retinopathy | 1. We may conclude that individuals homozygous for the deletion of GSTT1 are at an 2-fold-greater risk of diabetic retinopathy (DR), whereas the GSTM1 deficiency is associated with lower frequency of DR in type 2 diabetics. | 22377702 |
| Atherosclerosis | 1. The GSTT1-0 genotype and GSTT1-0/GSTM1-0 haplotype might be a potential determints of susceptibility to advanced atherosclerosis in patients with type 2 diabetes mellitus. | 22330623 |