| HBG2 |
| LOCUS ID | 3048 | ||||||||||
| GENE_SYMBOL | HBG2 | ||||||||||
| GENE NAME | hemoglobin subunit g | ||||||||||
| SYNONYMNS | TNCY, HBG-T1 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 128032 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product ( |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. Approximately 48 and 61 spots were identified in control and diabetic retinopathy respectively, of which three protein spots RBP1 (retinol-binding protein 1), NUD10 (Diphosphoinositol polyphosphohydrolase 3 alpha), NGB (neuroglobin) were down regulated and HBG2 (hemoglobin) and BY55 (CD 160 antigen) were upregulated in diabetic retinopathy. | 26129748 |