| HDAC3 |
| LOCUS ID | 8841 | ||||||||||
| GENE_SYMBOL | HDAC3 | ||||||||||
| GENE NAME | histone deacetylase | ||||||||||
| SYNONYMNS | HD3 RPD3 KDAC3 RPD3-2 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 48250 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger trans |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. HDAC3 activity/HDAC3 mRNA levels positively correlated to proinflammation, poor glycemic control, and insulin resistance. | 27904654 |