| HDAC4 |
| LOCUS ID | 9759 | |||||||||||||
| GENE_SYMBOL | HDAC4 | |||||||||||||
| GENE NAME | histone deacetylase | |||||||||||||
| SYNONYMNS | HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A | |||||||||||||
| CHROMOSOME | 2 | |||||||||||||
| HOMOLOGENE ID | 55946 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Thus, HDAC4 contributes to podocyte injury and is one of critical components of a signal transduction pathway that links renal injury to autophagy in diabetic nephropathy. |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. hyperglycemia impairsMiRNA-29a signaling to intensify HDAC4 actions that contribute to podocyte protein deacetylation and degradation as well as renal dysfunction. HDAC4, via epigenetic H3K9 hypoacetylation, reducesMiRNA-29a transcription. The renoprotective effects ofMiRNA-29a in diabetes-induced loss of podocyte integrity and renal homeostasis highlights the importance of post-translational acetylation reactions in podocyte microenvironments. IncreasingMiRNA-29a action may protect against diabetic podocytopathy. | 24717296 |
| Insulin resistance and inflammation | 1. In the setting of acute overnutrition, leptin triggers catecholamine-dependent increases in cAMP signaling that reduce inflammatory gene expression via the activation of the histone deacetylase HDAC4. | 24768298 |