| HDAC9 |
| LOCUS ID | 9734 | ||||||||||
| GENE_SYMBOL | HDAC9 | ||||||||||
| GENE NAME | histone deacetylase | ||||||||||
| SYNONYMNS | HD7 HD9 HD7b HDAC HDRP MITR HDAC7 HDAC7B HDAC9B HDAC9FL | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 128578 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of m |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. Subgroup and multifactor dimensionality reduction analyses (MDR) further found the gene-environment interactions among SNP rs2107595, body mass index, type 2 diabetes and hyperlipidemia in CAD risk and the severity of coronary atherosclerosis. Our data suggest that SNP rs2107595 may contribute to coronary atherosclerosis and CAD risk through a possible mechanism of regulating HDAC9 expression and gene-environment interactions. | 27494404 |