HGF
LOCUS ID3082
GENE_SYMBOLHGF
GENE NAMEhepatocyte growth fa
SYNONYMNSSF, HGFB, HPTA, F-TCF, DFNB39
CHROMOSOME7
HOMOLOGENE ID503
microRNAsNANA
GENE SUMMARY
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single

OBSERVATIONS

Complication Evidence PMID
Nephropathy1.expression of HGF inhibited renal expression of TGF-beta1 and reduced urine level of TGF-beta1 protein. Therefore, despite the effects of HGF on diabetic nephropathy being controversial, these observations suggest that supplementation of HGF is beneficial in ameliorating diabetic renal insufficiency in mice.15466268
Atherosclerosis1. Serum HGF concentration may be a new marker of atherosclerotic complications in patients with Type 2 DM.16759302
Neuropathy1. Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats.15734864
Dyslipidemia1. This study shows decreased serum anti-inflammatory miR-146a, increased pro-inflammatory IL-8 and increased HGF (a vascular/insular repair factor) as discriminating markers of failure of glucose control occurring on the background of obesity and dyslipidemia.25500583
Insulin resistance and inflammation1. HGF has a role in the metabolic flux of glucose in different insulin sensitive cell types; plays a key role in ?-cell homeostasis; and is capable of modulating the inflammatory response.30214428