| Complication | Evidence | PMID |
| Nephropathy | 1.expression of HGF inhibited renal expression of TGF-beta1 and reduced urine level of TGF-beta1 protein. Therefore, despite the effects of HGF on diabetic nephropathy being controversial, these observations suggest that supplementation of HGF is beneficial in ameliorating diabetic renal insufficiency in mice. | 15466268 |
| Atherosclerosis | 1. Serum HGF concentration may be a new marker of atherosclerotic complications in patients with Type 2 DM. | 16759302 |
| Neuropathy | 1. Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats. | 15734864 |
| Dyslipidemia | 1. This study shows decreased serum anti-inflammatory miR-146a, increased pro-inflammatory IL-8 and increased HGF (a vascular/insular repair factor) as discriminating markers of failure of glucose control occurring on the background of obesity and dyslipidemia. | 25500583 |
| Insulin resistance and inflammation | 1. HGF has a role in the metabolic flux of glucose in different insulin sensitive cell types; plays a key role in ?-cell homeostasis; and is capable of modulating the inflammatory response. | 30214428 |
