| HK2 |
| LOCUS ID | 3099 | ||||||||||
| GENE_SYMBOL | HK2 | ||||||||||
| GENE NAME | hexokinase 2 | ||||||||||
| SYNONYMNS | HKII, HXK2 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 37273 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Tuberculosis | 1. Two genes, HK2 and CD28, emerged as potential culprits in diabetes-increased TB susceptibility. | 22230325 |