| HLA-A |
| LOCUS ID | 3105 | ||||||||||
| GENE_SYMBOL | HLA-A | ||||||||||
| GENE NAME | major histocompatibi | ||||||||||
| SYNONYMNS | HLAA | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 128352 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 e |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. the induction of eight NFKB_IRFF_01?dependant genes was correctly predicted in progressive DN (B2M, CCL5/RANTES, CXCL10/IP10, EDN1, HLA-A, HLA-B, IFNB1, and VCAM1). | 17065335 |