| HLA-DQA1 |
| LOCUS ID | 3117 | ||||||||||
| GENE_SYMBOL | HLA-DQA1 | ||||||||||
| GENE NAME | major histocompatibi | ||||||||||
| SYNONYMNS | CD, GSE, DQ-A1, CELIAC1, HLA-DQA | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 123820 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APCB Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader pept |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. These data suggest the HLA-DQA1*0301 and HLA-DQA1*0501 alleles are markers of susceptibility for T2DM, and the HLA-DQB1*0501 allele is associated with a protective effect on DN in Han ethnicity of China. | 23671871 |