| HMGA1 |
| LOCUS ID | 3159 | ||||||||||
| GENE_SYMBOL | HMGA1 | ||||||||||
| GENE NAME | high mobility group | ||||||||||
| SYNONYMNS | HMG-R HMGIY HMGA1A | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 128226 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. HMGA1 enhanced Visfatin and VEGF gene expression in human embryonic kidney (HEK) 293 cells in hypoxic conditions, whereas HMGA1 knockdown in differentiated 3T3-L1 adipocytes reduced these effects. | 27445976 |